Renal Function Evaluation in Secondary Amyloidosis According to Location of Deposition

Abstract

It aimed to evaluate the renal functions according to the accumulation site of amyloid in patients diagnosed with secondary amyloidosis by renal biopsy. Fifty patients diagnosed with secondary amyloidosis, who referred to the nephrotic syndrome outpatient clinic included in the study. According to the findings of renal biopsy, only-glomerular amyloid deposition (group- 1) detected in 9 patients and glomerular+ tubulointerstitial deposition (group- 2) identified in 41 patients. Serum creatinine, creatinine clearance, and total proteinuria levels compared between groups at the time of presentation and on 3rd, 6th, 12th, and 24th months. Initial and subsequent serum creatinine, creatinine clearance, and total proteinuria levels not found to be significantly different between groups (p>0,05 for all). Among subjects with only-glomerular deposition, statistically significant descents in total proteinuria, when compared to initial levels, were observed from the beginning of the 6th month to the end of the 24th month (p<0,05). On the other hand, subjects with both glomerular + tubulointerstitial deposition, statistically significant descents in total proteinuria levels observed from the beginning of follow-up to the end of the 24th month (p<0,01). In subjects with both glomerular + tubulointerstitial accumulation, a statistically significant increase in serum creatinine, compared to baseline levels, observed in 12th and 24th months (p<0,01). According to the biopsy findings, progressive deterioration of renal functions and an increase in proteinuria were higher in patients with both glomerular and tubulointerstitial amyloid deposition than patients with only-glomerular removal.