Negative Effect of Cigarette Smoke: Black Garlic Opportunities for Prevention of Ovulation Disorders
DOI:
https://doi.org/10.31964/mltj.v10i1.585Keywords:
Black garlic extract, cortisol levels, follicle count, infertilityAbstract
Women's issues are primarily related to infertility. This study aimed to demonstrate that ovarian healing in wistar rats exposed to cigarette smoke was impacted by the administration of extracted black garlic. This research uses True Experimental methods in vivo in the laboratory to identify the cause and effect of the variables being tested. This method involves replication, randomization, and control. The design chosen was a post-test-only control group design, where the experimental group received treatment and the control group did not, without random selection. The results of the study showed that there was no effect due to exposure to cigarette smoke with an increase in cortisol and a decrease in the number of secondary follicles in the ovaries of female wistar rats as well as the administration of Black Garlic (Allium sativum) extract. Black garlic extract unaffected cortisol levels and the number of secondary follicles or repair of the ovaries due to exposure to cigarette smoke. Further research is needed in dosing black garlic extract or combining it with other ingredients to provide effective results.References
Agustina, E., Andiarna, F., & Hidayati, I. (2020). Uji Aktivitas Antioksidan Ekstrak Bawang Hitam (Black Garlic) Dengan Variasi Lama Pemanasan. Al-Kauniyah: Jurnal Biologi, 13(1), 39–50. https://doi.org/10.15408/kauniyah.v13i1.12114
Ahmed, T., & Wang, C. K. (2021). Black garlic and its bioactive compounds on human health diseases: A review. Molecules, 26(16). https://doi.org/10.3390/molecules26165028
Akpantah A.O., Oremosu A.A., Noronha C.C., Ekanem T.B., O., & A.O. (2005). Effect of Garcinia Kola Seed Extract on Ovulation, Oestrus Cycle and Foetal Development in Cyclic Female Sprague-Dawley Rats. Nigerian Journal of Physiological Sciences, 20(1–2), 58–62.
Amida, N., Lisdiana, L., Christijanti, W., & Iswari, R. S. (2021). Efek ekstrak black garlic terhadap kualitas spermatozoa tikus setelah dipapar asap rokok. Prosiding Semnas Biologi Ke-9, 9, 298–303.
Armadiyanti, W., Febrina, L., & Masruhim, M. A. (2018). Pengaruh Variasi Lama Pemaparan Asap Rokok terhadap Profil Kadar Malondialdehida pada Hewan Coba. Proceeding of Mulawarman Pharmaceuticals Conferences, 8(November), 35–40. https://doi.org/10.25026/mpc.v8i1.300
Armalini, R., & Friadi, A. (2019). Pengaruh Paparan Asap Rokok Terhadap Kadar Zink Dan Kortisol Pada Tikus Putih Hamil (Rattus Norvegicus). Jurnal Ilmu Keperawatan Dan Kebidanan, 10(1), 30. https://doi.org/10.26751/jikk.v10i1.582
Aryani, Hany Puspita;Santoso, B. (2019). Mekanisme Perbaikan Perkembangan Folikel Pada Rattus Norvegicus Model SOPK Dengan Resistensi Insulin Yang Diberi Ekstrak Sambiloto. Jurnal Medica Majapahit, 11.
De Angelis, C., Nardone, A., Garifalos, F., Pivonello, C., Sansone, A., Conforti, A., Di Dato, C., Sirico, F., Alviggi, C., Isidori, A., Colao, A., & Pivonello, R. (2020). Smoke, alcohol and drug addiction and female fertility. Reproductive Biology and Endocrinology, 18(1), 1–26. https://doi.org/10.1186/s12958-020-0567-7
Depkes RI. (2007). Keputusan Mentri Kesehatan RI No: 900/MENKES/VII/2007. Konsep Asuhan Kebidanan.
Dewita. (2021). Ekstrak bit merah (Beta vulgaris L) meningkatkan ekspresi reseptor Estrogen-Α pada Rattus norvegicus betina yang dipapar asap rokok. Femina: Jurnal Ilmiah Kebidanan, 1(1), 1–10.
Falahatian, S., Haddad, R., & Pakravan, N. (2022). Modulatory effects of R10 fraction of garlic (Allium sativum L.) on hormonal levels, T cell polarization, and fertility-related genes in mice model of polycystic ovarian syndrome. Journal of Ovarian Research, 15(1), 1–10. https://doi.org/10.1186/s13048-021-00926-6
Halliwell & Gutteridge. (2007). Free Radicals in Biology and Medicine. Fourth Edition. Oxford University Press In, 42–72.
Handayani, A R; Romsiah; Rikmasari, Y. (2020). Penetapan Kadar Senyawa S-allyl cysteine (SAC) Pada Ekstrak Black Garlic Secara Kromatografi Cair Kinerja Tinggi. Jurnal Ilmiah Bakti Farmasi, 2, 9–16.
Ibroham, M. H., Jamilatun, S., & Kumalasari, I. D. (2022). A Review: Potensi Tumbuhan-Tumbuhan Di Indonesia Sebagai Antioksidan Alami. Jurnal UMJ, 1–13.
Irmawati. (2021). ). Infertilitas dan Pendidikan Seks. CV. Cahaya Bintang Cemerlang.
Jumiati, fitria, S., & Rahmawati, ayu. (2012). 2899-Research Results-7586-1-10-20211005 (2). Prosiding SainsTeKes, 2, 187–14.
Juniantari, N. K. D., & Susanti, N. M. P. (2023). Pengolahan dan Pengembangan Bawang Putih (Allium sativum L.) Menjadi Bawang Hitam sebagai Agen Antiaterosklerosis. Prosiding Workshop Dan Seminar Nasional Farmasi, 2, 428–438. https://doi.org/10.24843/wsnf.2022.v02.p34
Kicińska, A. M., Maksym, R. B., Zabielska-Kaczorowska, M. A., Stachowska, A., & Babińska, A. (2023). Immunological and Metabolic Causes of Infertility in Polycystic Ovary Syndrome. Biomedicines, 11(6), 1–33. https://doi.org/10.3390/biomedicines11061567
Legowo, G. (2015). Manfaat Madu sebagai Antioksidan dalam Melawan Radikal Bebas dari Asap Rokok untuk Menjaga Kualitas Sperma. Majority, 4(8), 41–46.
Maggyvin, E., Barliana, M. I., Central, B., & Therapy, T. D. (2019). Farmaka Farmaka. 17, 107–118.
Margarisa, D., Rezaldi, F., Pruschia, I. D., Andry, M., Fadillah, M. F., Muhardiyanti, M., Jaya, H., Halimatusyadiah, L., & Nasution, M. A. (2023). Fermentasi kombucha bunga telang (Clitoria ternatea L) sebagai produk bioteknologi sederhana dalam memberikan reaksi farmakodinamik mencit (Mus musculus L) yang terpapar asap rokok dan morfometri ovarium. Journal of Pharmaceutical and Sciences, 1616–1625.
Moshfegh, F., Baharara, J., Namvar, F., Zafar-Balanezhad, S., Amini, E., & Jafarzadeh, L. (2016). Effects of date palm pollen on fertility and development of reproductive system in female Balb/C mice. Journal of HerbMed Pharmacology, 5(1), 23–28.
Nasution, A., Wirjatmadi, B., Brawijaya, M. A.-J. K., & 2016, U. (2016). Efek Preventif Pemberian Ekstrak Kulit Buah Naga Berdaging Super Merah (Hylocereus Costaricensis) terhadap Malondialdehid Tikus Wistar yang Dipapar Asap Rokok Preventive Effects of Giving Super Red Dragon Fruit (Hylocereus Costaricensis) Peel Extract Towa. Jurnal Kedokteram Brawijaya, 29(1), 21–24.
Nur Halimah, A., & Winarni, S. (2018). Paparan Rokok, Status Gizi, Beban Kerja Dan Infeksi Organ Reproduksi Pada Wanita Dengan Masalah Fertilitas Di RSI Sultan Agung Semarang. 6(4), 2356–3346.
Rahmadiani D. (2021). Ekstrak Pollen Kurma (Phoenix dactylifera L) Sebagai Terapi Infertilitas Pada Pria : Literatur Review. Jurnal Ilmiah Kesehatan Sandi Husada, 10, 1.
Ramdiana, Legiran. (2023). Literature Review: Stres Oksidatif dan Reproduksi Wanita. Jurnal Ilmu Kesehatan Masyarakat, 3, 12.
Setiyono, A., Prasetyo, B., & Maramis, M. (2015). Pengaruh Tingkat Stres dan Kadar Kortisol dengan Jumlah Folikel Dominan pada Penderita Infertilitas yang Menjalani Fertilisasi Invitro. Majalah Obstetri & Ginekologi, 23(3), 128. https://doi.org/10.20473/mog.v23i3.2078, M.
Sugiyono. (2010). Metode Penelitian Pendidikan Pendekatan Kuantitatif, kualitatif, dan R&D. Alfabeta.
Talakua, F. C., & Unitly, A. J. A. (2020). Efek Pemberian Ekstrak Etanol Rumput Kebar (Bhiophytum Petersianum Klotzsch) Terhadap Peningkatan Jumlah Folikel Pada Ovarium Tikus Rattus Norvegicus Terpapar Asap Rokok. Biofaal Journal, 1(2), 74–84. https://doi.org/10.30598/biofaal.v1i2pp74-84
Wahyuwardani, S., Noor, S. M., & Bakrie, B. (2020). Animal Welfare Ethics in Research and Testing: Implementation and its Barrier. Indonesian Bulletin of Animal and Veterinary Sciences, 30(4), 211. https://doi.org/10.14334/wartazoa.v30i4.2529
Wardhani, G. A. P. K., Azizah, M., & Hastuti, L. T. (2020). Nilai Total Flavonoid dalam Black garlic (Allium sativum L.) berdasarkan fraksi pelarut dan Aktivitas Antioksidannya. Jurnal Agroindustri Halal, 6(1), 020–027. https://doi.org/10.30997/jah.v6i1.2125.
Wiliyanarti, P. F., & Wahyullah, M. G. (2021). Pengaruh Ekstrak Bawang Hitam Terhadap Penurunan Kadar Glukosa Darah Pada Mencit. The Journal of Muhammadiyah Medical Laboratory Technologist, 4(1), 49. https://doi.org/10.30651/jmlt.v4i1.7269
World Health Organization. (2018). Conference of the Parties to the WHO Framework Convention on Tobacco Control. https://fctc.who.int/who-fctc/overview. Accessed on June 7, 2023.
World health statistics. (2019). Monitoring health for the SDGs, sustainable development goals. World Health Organization. https://iris.who.int/handle/10665/324835. Accessed on June 7, 2023.
Zettira, Z; Nisa, K. (2015). Analisis Hubungan Penggunaan Kontrasepsi Hormonal dengan Disfungsi Seksual pada Wanita. Majority, 4, 7.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Sari Wulan Asih, Tatit Nurseta, Kusworini Handono, Hendy Setyo Yudhanto
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Publishing your paper with Medical Laboratory Technology Journal (MLTJ) means that the author or authors retain the copyright in the paper. MLTJ granted an author(s) rights to put the paper onto a website, distribute it to colleagues, give it to students, use it in your thesis etc, even commercially. The author(s) can reuse the figures and tables and other information contained in their paper published by MLTJ in future papers or work without having to ask anyone for permission, provided that the figures, tables or other information that is included in the new paper or work properly references the published paper as the source of the figures, tables or other information, and the new paper or work is not direct at private monetary gain or commercial advantage.
MLTJ journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge. This journal is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License. This license lets others remix, transform, and build upon the material for any purpose, even commercially. MLTJ journal Open Access articles are distributed under this Creative Commons Attribution-ShareAlike 4.0 International License (CC BY-SA). Articles can be read and shared for All purposes under the following conditions:
BY: You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.SA: If you remix, transform, or build upon the material, you must distribute your contributions under the same license as the original.
