Nutritional Content, Subchronic Toxicity, and Antidysmenorrhea Activity of Instant Herbal Medicine Mixture of Red Ginger and White Ginger
DOI:
https://doi.org/10.31964/mltj.v11i2.685Keywords:
Antidysmenorrhe, ginger, Nutritional, ToxicityAbstract
Dysmenorrhea is menstrual pain that occurs in 69.8% of women. Ginger (Zingiber officinale) contains various secondary metabolites with anti-inflammatory properties. This study aims to determine its characteristics, including nutritional value and stability, product safety through toxicity testing, and product efficacy. The research stages include research ethics testing and the production of instant powder from a mixture of red and white ginger. Nutritional content analysis included total fat, saturated fat, protein, and carbohydrates. Physical and chemical stability testing was carried out for three months. Subchronic toxicity testing used Wistar rats for 28 days by drawing blood before and after treatment, accompanied by liver delivery. Blood samples were analyzed for SGPT and SGOT levels. The test was conducted on 10 women aged 18-20, divided into two groups. The treatment group was given 20 grams of instant ginger in the morning and evening for 10 days, and compared with the control group without treatment. Pain was measured using a Visual Analog Scale (VAS) before and after the study. The study showed that instant ginger herbal medicine contained 0.83% total fat, 0.17% saturated fat, 3.73% total protein, and 35.42% total carbohydrates. The stability test results showed no changes in the physical and chemical parameters of the test. The results of the subchronic toxicity test showed that the body weight of mice, liver weight, SGOT levels, and SGPT levels of mice were normal. The activity test showed a decrease in pain from before to after administration of instant ginger, with an average VAS value of 7.8 to 4.2. This study concluded that instant ginger, a mixture of red and white ginger, has good nutritional content, is physically and chemically stable, is non-toxic, and is effective in reducing dysmenorrhea.References
Achmadi, E. R. (2023). Strategies Managing Smart Packaging for Food Application. Journal of Food and Agricultural Product, 3(1), 9–26. https://doi.org/10.32585/jfap.v3i1.3593
Adams, J. D., & Wang, X. (2015). Control of Pain with Topical Plant Medicines. Asian Pacific Journal of Tropical Biomedicine, 5(4), 268–273. https://doi.org/10.1016/S2221-1691(15)30342-7
Adha, K. F. (2023). Uji Toksisitas Kronis Formula Ekstrak Daun Salam (Syzygium polyanthum (Wight) Walp.) Terhadap Gambaran Hati Tikus Putih Sprague dawley [Skripsi]. Universitas Islam Negeri Syarif Hidayatullah.
Adiyasa, M. R., & Meiyanti, M. (2021). Pemanfaatan Obat Tradisional di Indonesia: Distribusi dan Faktor Demografis yang Berpengaruh. Jurnal Biomedika dan Kesehatan, 4(3), 130–138. https://doi.org/10.18051/JBiomedKes.2021.v4.130-138
Afdhaliah, N., Kusumaningrum, I., & Zuraida, I. (2024). Karakteristik Fisikokimia Serbuk Minuman Jahe Merah Instan dengan Penambahan Rumput Laut (Kappaphycus alvarezii). Jurnal Pengolahan Hasil Perikanan Indonesia, 27(3), 252–265. https://doi.org/10.17844/jphpi.v27i3.47028
Ahnafani, M. N., Aulia, N., Lestrari, N. L. M., Ngongo, M., & Hakim, A. R. (2024). Jahe (Zingiber officinale): Tinjauan Fitokimia, Farmakologi, dan Toksikologi. Jurnal Ilmu Kedokteran dan Kesehatan, 11(10), 1992–1998.
Andini, N., & Rahmadiyah, D. C. (2022). Penerapan Kompres Hangat Jahe Untuk Menurunkan Nyeri Pada Sendi: Studi Kasus. Journal of Health and Cardiovascular Nursing, 2(2), 91–107.
Armour, M., Parry, K., Manohar, N., Holmes, K., Ferfolja, T., Curry, C., MacMillan, F., & Smith, C. A. (2019). The Prevalence and Academic Impact of Dysmenorrhea in 21,573 Young Women: A Systematic Review and Meta-Analysis. Journal of Women’s Health, 28(8), 1161–1171. https://doi.org/10.1089/jwh.2018.7615
Badan Pusat Statistik. (2024). Produksi Tanaman Biofarmaka Menurut Jenis Tanaman di Provinsi Kalimantan Selatan. https://kalsel.bps.go.id/id/statistics-table/3/VVZNelkycEdWM2t5V2poTFltOVVURWR0WWs1Mlp6MDkjMw==/produksi-tanaman-biofarmaka-menurut-kabupaten-kota-dan-jenis-tanaman-di-provinsi-kalimantan-selatan--2022.html
Bahrami, A., Sadeghnia, H., Avan, A., Mirmousavi, S. J., Moslem, A., Eslami, S., Heshmati, M., Bahrami-Taghanaki, H., Ferns, G. A., & Ghayour-Mobarhan, M. (2017). Neuropsychological Function in Relation to Dysmenorrhea in Adolescents. European Journal of Obstetrics & Gynecology and Reproductive Biology, 215, 224–229. https://doi.org/10.1016/j.ejogrb.2017.06.030
Bulgaru, V., Mazur, M., Netreba, N., Paiu, S., Dragancea, V., Gurev, A., Sturza, R., Şensoy, İ., & Ghendov-Mosanu, A. (2025). Characterization of Plant-Based Raw Materials Used in Meat Analog Manufacture. Foods, 14(3), 483–502. https://doi.org/10.3390/foods14030483
Chaerunnisa, S., Amalia, L., & Hutami, R. (2024). Karakteristik Kimia dan Sensori Bandrek Instan Pasta dengan Penambahan Sari Kurma Sukari (Phoenix dactylifera. L) dan Ekstrak Jahe Merah (Zingiber offinale var. Rubrum). Karimah Tauhid, 3(3), 2616–2637. https://doi.org/10.30997/karimahtauhid.v3i3.12332
Dewi, V. K., Barkinah, T., Kirana, R., & Rizki, M. I. (2024). The Analgesic Effect and Toxicity of Red and White Ginger on Mus Musculus with the Acetate Writhing Test. Medical Laboratory Technology Journal, 10(2), 95–105. https://doi.org/10.31964/mltj.v10i2.611
Dipayana, I. M., Dewi, N. P., Magfira, Tandi, J., Wirawan, W., Rachmawati, M., & Azizah, N. (2024). Sub-Chronic Toxicity Test of Purple Leaf Extract on the Kidney Histopathology of Male White Rats. Jurnal Penelitian Pendidikan IPA, 10(8), 4572–4578. https://doi.org/10.29303/jppipa.v10i8.8312
Elsera, C., Wulan Agustina, N., Sat Titi Hamranani, S., & Nur Aini, A. (2022). Pengetahuan Penatalaksanaan Dismenore Remaja Putri. INVOLUSI: Jurnal Ilmu Kebidanan, 12(2), 48–54. https://doi.org/10.61902/involusi.v12i2.427
Esan, D. T., Ariyo, S. A., Akinlolu, E. F., Akingbade, O., Olabisi, O. I., Olawade, D. B., Bamigboye, T. O., & Ogunfowokan, A. A. (2024). Prevalence of Dysmenorrhea and its Effect on the Quality of Life of Female Undergraduate Students in Nigeria. Journal of Endometriosis and Uterine Disorders, 5, 100059. https://doi.org/10.1016/j.jeud.2024.100059
Harianja, W. Y., & Septyani, A. (2021). The Effect of Giving Pure Honey Drink on The Reduction of Menstrual Pain (Dysmenorrhea) In Adolescent Private Vocational School. Jurnal Profesi Bidan Indonesia, 1(2), 15–21.
Jayanti, M. D., & Winarni, W. (2024). Pengaruh Pemberian Ekstrak Jahe terhadap Penurunan Intensitas Dismenore pada Remaja. Jurnal Medika Nusantara, 2(3), 263–273. https://doi.org/10.59680/medika.v2i3.1312
Mahbub, K., Mahfur, M., Indriono, A., Ardianto, H., Sona, S., & Kurniawan, A. (2024). Pemanfaatan Potensi Jahe Menjadi Jamu Instan Berbasis Home Industri. Jurnal Pengabdian kepada Masyarakat Nusantara, 5(2), 2847–2854. https://doi.org/10.55338/jpkmn.v5i2.3420
Manno, M. R., & Setianto, A. B. (2022). Penggunaan Campuran Avicel PH 101 dan Laktosa Sebagai Bahan Pengisi Pada Tablet Dispersi Padat Tadalafil dengan Metode Granulasi Basah. Jurnal Ilmu Farmasi dan Farmasi Klinik, 19(2), 95–102.
Nabilah, T. U., & Mentari, I. A. (2023). Formulation and Physical Stability Test of Essence Sheet Mask Preparation from Kokang Leaf Extract (Lapisanthes amoena). Jurnal Mandala Pharmacon Indonesia, 9(1), 80–86. https://doi.org/10.35311/jmpi.v9i1.302
Prasuma, G. S., Qotrunnada, E. N., & Charisma, S. L. (2024). Uji Aktivitas Hepatoprotektor Ekstrak Etanol Herba Tapak Liman (Elephantopus scaber L.) terhadap Tikus Jantan Galur Wistar yang Diinduksi Isoniazid. Pharmaceutical Journal of Indonesia, 20(2), 183–188.
Putra, B. R., Yuswar, M. A., Rizkifani, S., & Nawawi, J. D. H. (2024). Gambaran Visual Analog Scale (VAS) Pasien Hipertensi di Puskesmas Siantan Tengah Pontianak. Journal Pharmacy of Tanjungpura, 1(2), 57–66.
Qomara, W. F., Musfiroh, I., & Wijayanti, R. (2023). Review: Evaluasi Stabilitas dan Inkompatibilitas Sediaan Oral Liquid. Majalah Farmasetika, 8(3), 209. https://doi.org/10.24198/mfarmasetika.v8i3.44346
Rahayu, S., & Anisah, N. (2021). Pengaruh Variasi Konsentrasi Amprotab Sebagai Desintegrant Terhadap Sifat Fisik Tablet Ekstrak Buah Pare (Momordica charantia L.). Jurnal Ilmiah Ibnu Sina, 6(1), 39–48. https://doi.org/10.36387/jiis.v6i1.572
Rasyad, A. A., Aisah, A., Lidia, L., & Meisyayati, S. (2022). Sub Chronic Toxicity Effect oof Combination of Herbal Juice on the Function and Histopathology Feature of Male Wistar Rat Liver. Jurnal Ilmiah Farmasi, Special Edition, 121–127. https://doi.org/10.20885/jif.specialissue2022.art14
Rumaseuw, E. S., Iskandar, Y., & Halimah, E. (2022). Acute Toxicity Test of Black Garlic Ethanol Extract. Indonesian Journal of Biological Pharmacy, 2(1), 1–9.
Sadino, A. (2017). Review: Aktivitas Farmakologis, Senyawa Aktif dan Mekanisme Kerja Rambutan (Nephelium lappaceum L.). Farmaka, 15(3), 16–26.
Saputro, M. R., Windhu Wardhana, Y., & Wathoni, N. (2021). Stabilitas Hidrogel dalam Penghantaran Obat. Majalah Farmasetika, 6(5), 421. https://doi.org/10.24198/mfarmasetika.v6i5.35705
Saristiana, Y., Prasetyawan, F., Wahab, C. S., & Aina, L. (2023). Uji Keseragaman Bobot Resep Racikan Terhadap Kualitas Serbuk Bagi (Pulveres) Paracetamol Pada Pasien Anak Di Apotek Khodijah Kabupaten Jombang Tahun 2022. Jurnal Inovasi Farmasi Indonesia, 4(2), 81–87.
Sijid, S. A., Muthiadin, C., Zulkarnain, Z., & Hidayat, Ar. S. (2020). Pengaruh Pemberian Tuak Terhadap Gambaran Histopatologi Hati Mencit (Mus musculus) ICR Jantan. Jurnal Pendidikan Matematika dan IPA, 11(2), 193. https://doi.org/10.26418/jpmipa.v11i2.36623
Sumayyah, S., & Salsabila, N. (2017). Obat Tradisional: Antara Khasiat dan Efek Sampingnya. Majalah Farmasetika, 2(5), 1. https://doi.org/10.24198/farmasetika.v2i5.16780
Widarti, W., & Nurqaidah, N. (2019). Analisis Kadar Serum Glutamic Pyruvic Transaminase (SGPT) dan Serum Glutamic Oxaloacetic Transaminase (SGOT) Pada Petani yang Menggunakan Pestisida. Jurnal Media Analis Kesehatan, 10(1), 35–43. https://doi.org/10.32382/mak.v10i1.984
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Vonny Khresna Dewi, Rita Kirana, Muhammad Ikhwan Rizki
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Publishing your paper with Medical Laboratory Technology Journal (MLTJ) means that the author or authors retain the copyright in the paper. MLTJ granted an author(s) rights to put the paper onto a website, distribute it to colleagues, give it to students, use it in your thesis etc, even commercially. The author(s) can reuse the figures and tables and other information contained in their paper published by MLTJ in future papers or work without having to ask anyone for permission, provided that the figures, tables or other information that is included in the new paper or work properly references the published paper as the source of the figures, tables or other information, and the new paper or work is not direct at private monetary gain or commercial advantage.
MLTJ journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge. This journal is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License. This license lets others remix, transform, and build upon the material for any purpose, even commercially. MLTJ journal Open Access articles are distributed under this Creative Commons Attribution-ShareAlike 4.0 International License (CC BY-SA). Articles can be read and shared for All purposes under the following conditions:
BY: You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.SA: If you remix, transform, or build upon the material, you must distribute your contributions under the same license as the original.
