Impact of Malaria on Hematological Profiles, Iron Indices, and G6PD Activity in Pregnant Women

Fidelis Ohiremen Oyakhire; Patricia Ejenawome Dele-Ochie; Juliana Edusola Olaniyan; Valentine Ikalumhe; Babatunde Ishola Gabriel Adejumo; Samson Efenarhua; Osamwonyi Ernest  Igbinovia; Emmanuel Onosetale Afeikhena; Adebukola Adisa Ekoh-Jolly

doi:10.31964/mltj.v12i1.739

Authors

Fidelis Ohiremen Oyakhire Department of Medical Laboratory Science, Faculty of Applied Health Sciences, Edo State University, Iyamho, Edo State, Nigeria
Patricia Ejenawome Dele-Ochie Department of Medical Laboratory Science, Southern Delta University, Ozoro, Delta State, Nigeria
Juliana Edusola Olaniyan Department of Chemical Pathology, Federal Medical Center, Owo, Ondo State, Nigeria
Valentine Ikalumhe Department of Medical Laboratory Science, Faculty of Applied Health Sciences, Edo State University, Iyamho, Edo State, Nigeria
Babatunde Ishola Gabriel Adejumo Department of Medical Laboratory Science, University of Benin, Benin City, Edo State, Nigeria
Samson Efenarhua Department of Natural Science, Faculty of Science and Technology, Middlesex University, London, United Kingdom
Osamwonyi Ernest Igbinovia Department of Laboratory Medicine, Swansea Bay University Health Board, Wales, United Kingdom
Emmanuel Onosetale Afeikhena Department of Pathology, Asaba Specialist Hospital, Asaba, Delta State, Nigeria
Adebukola Adisa Ekoh-Jolly Department of Medical Laboratory Science, Faculty of Allied Health Sciences, University of Medical Sciences, Ondo, Ondo State, Nigeria

DOI:

https://doi.org/10.31964/mltj.v12i1.739

Keywords:

Anemia, glucose-6-phosphate dehydrogenase activity, hematological profiles, iron indices malaria, serum iron

Abstract

The global prevalence and impact of malaria on pregnancy highlight a significant public health challenge that demands enhanced preventive measures and targeted interventions. The study aimed to assess the hematological, iron, and G6PD status among pregnant women infected with Plasmodium falciparum. We performed a comparative cross-sectional study among two hundred (200) pregnant women infected with Plasmodium falciparum, who attended Edo Specialist Hospital, Benin City, to assess the hematological, iron, and G6PD status compared with fifty (50) Plasmodium falciparum-free pregnant women as controls. Hematological parameters, iron, TIBC (total iron binding capacity), and G6PD activity were assessed using a hematology auto analyzer and spectrophotometric methods, respectively. Data obtained were analyzed using SPSS (IBM v26). Independent t-test and one-way analysis of variance (ANOVA) were used for continuous variables, and chi-square was used for categorical variables. Pregnant women infected with Plasmodium falciparum had 8.70%, 9.42%, 14.44%, 8.1%, 20.17%, 16.72%, 11.31%, and 27.8% reduction in red blood cell, hemoglobin, iron, packed cell volume, G6PD, total iron binding capacity, monocyte, and lymphocyte levels, respectively, compared to Plasmodium falciparum-free pregnant women as controls (p<0.05). In addition, the levels of white blood cell, platelets, and neutrophils witness 15.58%, 10.85%, and 24.02% increase in pregnant women infected with Plasmodium falciparum compared with plasmodium falciparum free pregnant women as controls (p<0.05). No significant differences were observed in serum iron and G6PD levels across gestational ages (p>0.05). The findings underscore the need of regular monitoring of hematological and biochemical parameters in pregnant women infected with Plasmodium falciparum in order to enhance policy on malaria prevention and screening in endemic regions.

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